Epiduo Gel 2.5% – Acne Cream (45g)


  • Effective Antibiotic-Free Acne Cream
  • Active Ingredients: Adapalene And Benzoyl Peroxide
  • See Improvement Within 1-4 Weeks
  • Buy Online From UK Registered Pharmacy
  • Includes Free Prescription

Epiduo Gel is an effective treatment for acne. Epiduo acne cream contains two active ingredients to help treat spots: Adapalene which targets the skins acne-causing processes, and Benzoyl Peroxide which is an antimicrobial agent, softening and peeling the outer layer of skin. Apply Epiduo 2.5% Gel to clean skin once a day and you should see improvement to the affected area within 1 to 4 weeks.




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Buy Epiduo Gel Online UK

My Pharmacy offers the best place to buy Epiduo gel online UK with next day delivery available within the UK. To purchase Ventolin Epiduo gel, you will need a prescription, which is available through our free online consultation service. Each item you purchase will be sent via secure and discreet packaging to ensure that you receive your medicine in a complete and efficient manner.

What is Epiduo Gel?

Epiduo is a treatment for mild to moderate acne which can be used by patients as young as nine years old. It contains two active ingredients- Adapalene and Benzoyl peroxide which simultaneously to help reduce the acne that is present and prevent any occurring in the future. They improve the level of inflammation, which helps people who tend to get red, inflamed pimples. Adapalene is a retinoid which acts specifically on the skin process that causes acne. It helps shed dead skin cells and unblock pores to stop blemishes from reoccurring. Benzoyl peroxide is known as an antimicrobial which fights the bacteria that cause acne outbreaks.

We are often asked “What Epiduo Gel?”

As both ingredients work so effectively together, it can reduce the amount of treatment you may need to re-purchase. When the specific amount is used on the affected area, refills will only be required once every three months.

Epiduo is currently only available via prescription however the active ingredients contained within the gel (Adapalene & Benzoyl peroxide) can be purchased over the counter and as prescription medications.

For more general information about Acne, click here to be directed to the NHS website.

How Long does it take for Epiduo Gel to work?

The amount of time it takes for Epiduo 2.5 gel to show results is usually between eight to twelve weeks. If you do not see any improvement in this time it is advised to discontinue this treatment and seek an alternative.

Once you have started treatment, you may experience an initial flare-up which is normal and can usually make the skin worse before improving. This flare-up can last up to four weeks before improvement. This occurs because the gel is bringing any current debris on the skin to come to the surface. This should not happen after eight weeks of continued use.

After eight weeks of using the gel, your skin should be showing signs of improvement however if this does not happen, please consult your doctor or dermatologist.

How Long Does it Take for Epiduo Gel to Work?

How long does it take for Epiduo Gel to work? Once treatment has been started, you may notice an initial flare-up, this is common and can usually go worse before improving. The flare-up can last up four weeks before improving.

This happens because the gel is making any current debris on the skin rise to the surface, this is usually not the case after eight weeks of the continued appliance.

After the eight week mark, your skin should be showing signs of improvement, if this isn’t the case, consult with your doctor or dermatologist.

Epiduo Gel How to Apply

Below is an overview on how to use Epiduo gel- for a further in-depth guide please refer to the patient information leaflet for additional guidelines. If you are unsure of any of the information, please consult your doctor or pharmacist.

  • apply a pea-sized amount over clean and dry skin, once a day at bedtime- avoid the eyes, lips and nostrils.
  • After using Epiduo gel, wash your hands thoroughly.
  • Duac Gel or Epiduo Gel

    Differences between Duac Gel and Epiduo Gel

    One of the biggest differences people notice is the significant increase in dryness of using Epiduo which causes higher volumes of water loss on the skin compared to using Duac. Some users also experienced mild burning and stinging when using Epiduo gel compared to Duac Gel.

    Another difference is both products contain changed active ingredients with Epiduo gel containing Adapalene and Benzoyl peroxide, whilet Duac Gel contains Clindamycin and Benzoyl peroxide.

    Clindomycin works by slowing down and/or stopping the growth of bacteria and is used to treat certain types of bacterial infections, including those on the skin.
    In regards to common side effects , there are not many differences between the two medications.

    Duac Gel is available to be purchased from My Pharmacy UK, click here for a range of pricing options.

    “I have been suffering from adult acne for over a year and finally plucked up the courage to see the dermatologist for the first time in my life and boy, am I glad I did! I have been using Epiduo paired with an oral antibiotic (Solodyn) for about 1 1/2 months and my skin already looks better. I did have the redness on my first application (like a sunburn) and there was a good amount of dryness around my mouth for the first few weeks, but if you stop applying to those dry areas, it gets better. I also experienced some burning – but only in the dry areas. I didn’t really have an initial breakout, just a few little pimples that were NOTHING like the huge cysts that I had been so used to getting. Another pro – my skin is SO SOFT now.” –

    (User Reviews for Epiduo, 2019)

    Buy Epiduo Gel UK next day delivery from My Pharmacy UK.

    Epiduo Acne Gel Side Effects

    Here are some of the differences between Duac Gel and Epiduo Gel –

    One of the first differences a lot of people notice is the significant increase in dryness when using Epiduo compared to Duac, with the former causing higher volumes of evaporative water loss on the skin.

    Users testing the difference between the two also noted a higher frequency of adverse perceptions, including mild burning and stinging when using Epiduo Gel compared to Duac Gel.

    Overall the two of them barely have any significant differences between them when comparing common side effects.

    Another difference is that both uses changed active ingredients. Epiduo gel contains Adapalene and Benzoyl peroxide, whilst Duac Gel contains Clindamycin and Benzoyl peroxide. Clindamycin works by slowing or stopping the growth of bacteria, treating certain types of bacterial infections, including the skin.

    Duac Gel is available to be purchased from My Pharmacy UK, click here for a range of pricing options.

    Epiduo Acne Gel Side Effects

    Like with all medicine, Epiduo 2.5 gel can have side effects, but these aren’t experienced by everyone.

    Stop using this product and seek immediate medical attention if you develop throat tightness or swelling of the eyes, face, lips or tongue, feel faint, or have difficulty breathing. The frequency at which these side effects occur is not known. This could mean you have an adverse allergic reaction to the medicine.

    Some of the common side effects include –



    Skin irritation

    Burning sensation

    Dry skin

    Skin rash

    Uncommon side effects include –

    Itchy skin


    For more information on the side effects of Epiduo Gel, please consult the patient information leaflet located here.

    Alternatives to Epiduo Gel 30g

    My Pharmacy UK is the best place to Buy Epiduo Gel UK.

    If Epiduo isn’t viable for you, here are some alternatives to Epiduo Gel 30g –

    Duac Gel

    Zineryt Solution 30ml

    Oxytetracycline Tablets

    Differin Cream

    Additional information


    X1, X2


    Acne is a very common skin condition that affects many people at some point in their life. For most people, it begins during puberty and tends to resolve by the late teens or early twenties, but it can persist for longer for some. It causes spots, blackheads, oily skin and can sometimes make the skin hot or painful to the touch.

    The areas acne will develop are:

    Face – this affects almost everyone with acne
    Back – this affects more than half of people with acne
    Chest – this affects around 15% of people with acne

    Types of spots

    The six main types of spots caused by acne are:

    Blackheads – these are small black or yellowish bumps that develop on the skin. They are not filled with dirt but are black because the inner lining of the hair follicle produces pigmentation (colouring).
    Whiteheads – These have a similar appearance to blackheads but may be firmer and won’t empty when squeezed.
    Papules – These are small red bumps that may feel tender or sore.
    Pustules – Similar to papules, pustules have a white tip in the centre which is caused by a build-up of pus.
    Nodules – these are large hard lumps that build up beneath the surface of the skin and can be painful.
    Cysts – these are the most severe type of spots caused by acne. Like boils, they are large lumps which are filled with pus which carry a risk of causing permanent scarring.

    What can I do if I have acne?

    Aside from treatment, there are self-help techniques that can help with your acne which include:

  • Do not wash affected areas of skin more than twice a day as frequent washing can irritate the skin and make symptoms your worse.
  • Ensure that you wash the affected area with a mild soap or cleanser and lukewarm water. Using very hot or cold water can make your acne worse.
  • Do not try to “clean out” blackheads or squeeze spots as this can make them worse and lead to permanent scarring.
  • Try to avoid using too much make-up and cosmetics which can aggravate your skin.
  • Use water-based products that are described as non-comedogenic -these products are formulated not to cause blocked pores
  • Make sure you remove make-up completely before going to bed.
  • If you suffer from dry skin, use a fragrance-free, water-based emollient.
  • Whilst regular exercise does not improve acne, it can boost your mood and improve your self-esteem. Make sure you shower as soon as possible after exercising, as sweat can irritate your acne.
  • Wash your hair regularly and try to avoid letting your hair fall across your face.
  • Whilst acne cannot be cured, it can be treated and controlled with treatment such as creams, lotions and gels specifically designed for acne.

    If you develop acne it is best to consult your pharmacist for advice. They may recommend products containing a low concentration of benzoyl peroxide (this must be used carefully as the ingredient can bleach clothing).

    If you develop severe acne or it begins to appear on your chest and back, it may require treatment with antibiotics or stronger creams which will only be available through prescription.

    Please note treatments can take up to three months to begin to show results. Once they do, the effects can be very promising.

    Who’s affected?

    Acne is most common in teenagers and younger adults with around 80% of people who suffer aged 11 to 30 years old. Most people will have acne for several years intermittently before their symptoms will begin to improve as they get older and tends to be resolved by their mid-twenties.


    Your doctor will be able to diagnose acne by examining your skin, this will involve assessing your face, chest and back for different types of spots such as blackheads, whiteheads or nodules. The number of spots you have and the degree of how painful and inflamed they are will determine how sever your acne is and will determine the course of treatment you need.

    There are four grades used to measure the severity of acne:

    Four grades can be used to measure the severity of acne:

    grade 1 (mild) – the acne is mostly confined to whiteheads and blackheads, with just a few papules and pustules
    grade 2 (moderate) – there are multiple papules and pustules, which are mostly confined to the face
    grade 3 (moderately severe) – there will be many papules and pustules, including occasional inflamed nodules. The back and chest will also be infected by acne
    grade 4 (severe) – there will be many large, painful pustules and nodules

    Acne in women

    For support and to read about other people’s experiences of living with and coping with acne, there are several blogs and sites on the internet such as talkhealth which provides free acne support. The Mix also has a website and helpline for teenagers and young people who may be struggling emotionally with acne issues and other difficulties.

    Make-up can help cover up scars, particularly those on the face. You can buy camouflage make up over the counter which is specifically designed to cover up scars. You can also consult your doctor for further advice and support.

    If you are interested in learning more about covering a mark, scar, non-infectious skin condition or a tattoo, you can also visit the Changing Faces skin camouflage service or call 0300 012 0276.

    Further Information

    Further information can be found on the manufacturers
    Paitient Information Leaflet and printed if required.

    Possible side effects

    Like all medicines, this medicine can cause side effects, although not everybody gets them.

    Epiduo may cause the following side effects at the site of application.

    Common side effects (may affect up to 1 in 10 people)

    dry skin
    local skin rash (irritative contact dermatitis)
    burning sensation
    irritation of the skin
    Uncommon side effects (may affect up to 1 in 100 people)

    itching of the skin (pruritus)
    Not known (frequency cannot be estimated from the available data): swelling face, allergic contact reactions, swelling of the eyelid, tightness in the throat, pain of skin (stinging pain), blisters (vesicles).

    If skin irritation appears after application of Epiduo, it is generally mild to moderate, with local signs as redness, dryness, scaling, burning and pain of skin (stinging pain), which peak during the first week and resolve without additional treatment.

    Do not use Epiduo:

    if you are allergic to the active substances or any of the other ingredients of this medicine (listed in section 6).
    Warnings and precautions

    You should not use Epiduo on areas where you have cuts, scrapes or eczema.
    Make sure Epiduo does not get into your eyes, mouth or nostrils, and other very sensitive areas of the body. Should this occur wash these areas immediately with plenty of warm water.
    Avoid excessive exposure to sunlight and UV lamps.
    Avoid getting Epiduo on your hair or coloured fabrics as it may bleach them and wash your hands thoroughly after you have used the medicine.